| First President of USA | George Washington |
| First Vice-President of USA | John Adams |
| First Chief Justice of USA | John Jay |
| First Speaker of the US House of Representatives | Frederick Muhlenberg |
| First Chair of the Federal Reserve | Charles Hamlin |
| First Attorney General of USA | Edmond Randolph |
| First woman to be the Vice-President of USA | Kamala Harris |
| First woman to be the Attorney General of USA | Janet Reno |
| First woman to be the Speaker US House of Representatives | Nancy Pelosi |
| First woman to be elected to the US House of Representatives | Jeannette Rankin |
| First woman Senator (appointed) | Rebecca Latimer Felton |
| First woman to be elected to the Senate | Hattie Caraway |
| First man from USA to go into space | Alan Shepard |
| First man from USA to take a space walk | Ed White (1965) |
| First woman from USA to go into space | Sally Ride |
| First woman to fly solo across the Atlantic Ocean | Amelia Earhart |
| First Chief of Staff of the United States Army | Lt Gen Samuel B.M. Young |
| First Chief of Staff of the United States Air Force | General Carl A. Spaatz |
| First Chief of Naval Operations | Admiral William S. Benson |
| First American to win the Nobel Prize | Theodore Roosevelt (1906 - Peace) |
| First American to win the Nobel Prize in any of the sciences | Albert Michelson (1907 - Physics) |
| First American to win the Nobel Prize for literature | Sinclair Lewis (1930) |
| First American woman to win the Nobel Prize | Jane Addams (1931 - Peace) |
| First American to successfully summit Mount Everest | Jim Whittaker (1963) |
| First American woman to summit Mount Everest | Stacy Allison (1988) |